A Maloine, ParisĬrain B, Cotman C, Taylor D, Lynch G (1973) A quantitative electron microscopic study of synaptogenesis in the dentate gyrus of the rat. J Comp Neurol 190:87–114Ĭajal SR y (1911) Histologie du Système Nerveux de l'Homme et des Vertébrés. Neurogenesis examined with 3H-thymidine autoradiography. Exp Brain Res 13:222–238īayer SA (1980) Development of the hippocampal region in the rat. Neurosci Lett 58:33–40Īndersen P, Bliss TVP, Skrede KK (1971) Lamellar organization of hippocampal excitatory pathways. J Comp Neurol 195:51–86Īmaral DG, Kurz J (1985) The time of origin of cells demonstrating glutamic acid decarboxylase-like immunoreactivity in the hippocampal formation of the rat. A light and electron microscopic study of the mossy fibers and their expansions. J Comp Neurol 182:851–914Īmaral DG, Dent JA (1981) Development of the mossy fibers of the dentate gyrus: I. Our results thus indicate that the plexus of inhibitory GABAergic axons is already well developed at a stage when the target neurons, the granule cells, are still being formed.Īmaral DG (1978) A Golgi study of cell types in the hilar region of the hippocampus in the rat. Electron microscopy of the immunostained axon plexus revealed numerous GABAergic terminals that formed symmetric synaptic contacts, mainly on shafts of differentiating dendrites but also on cell bodies of granule cells. At least some of these symmetric synapses were GABAergic because immunostaining of Vibratome sections from the same postnatal stage (P5) demonstrated a well-developed GABAergic axon plexus in the fascia dentata (antibodies against glutamate decarboxylase (GAD), the GABA synthesizing enzyme). Their membrane specializations were symmetric. Incoming synapses on the differentiating granule cells were mainly found on dendritic shafts. ![]() ![]() Characteristic features of the dendritic development of granule cells were i) occurrence of varicose swellings along the dendrites, ii) growth cones on dendritic tips, iii) transient formation of basal dendrites, and iv) progressive development of dendritic spines. ![]() Due to the long postnatal formation of these cells it was possible to describe a sequence of maturational stages coexisting on the same postnatal day (P5). The impregnated granule cells were gold-toned allowing for a fine structural study of the same identified neurons and of the input synapses onto their cell bodies and dendrites. Golgi impregnation was used to study the dendritic differentiation of granule cells in the rat fascia dentata.
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